29 August

Aminocaproic acid - instruction , use, contraindications

Pharmacological action

aminocaproic acid is antihemorrhagic and hemostatic drug that has a specific hemostatic effect in bleeding related to increased fibrinolysis (clot dissolving process).This drug helps to reduce the capillary permeability and inhibition of fibrinolysis in general.Aminocaproic acid enhances liver antitoxic ability, exhibits moderate anti shock and anti-allergic activity.The drug can improve some of the indicators of specific and nonspecific defense with SARS.

After application of the maximum concentration of aminocaproic acid in the blood is observed within 2-3 hours.Plasma protein binding is virtually absent.The bulk of the drug is excreted unchanged by the kidneys, while 10-15% biotransformed in the liver.Accumulation aminocaproic acid occurs only if there is a disruption of the urinary function.

Indications aminocaproic acid

This drug is used when necessary to stop the bleeding with increased fibrinolytic activity of blood and tissue that accompany surgery and va

rious pathological conditions.Thus, aminocaproic acid effective for bleeding after surgery on the pancreas, lung, prostate, thyroid, as well as premature placental abruption, acute pancreatitis, liver diseases.

Dosing aminocaproic acid

This drug is available in the form of a powder for oral use (1 packet corresponds to 1 g) and solution for infusion 5%.

powder taken orally during or after meal with sweet water or previously dissolved in it.According to the instructions aminocaproic acid, a single dose of the drug for oral administration is calculated as follows: 0.1 g multiplied by the patient's weight in kilograms.The daily dose should be divided into 3-6 receptions, it usually corresponds to 5-24 g aminocaproic acid

children calculated by multiplying 0.05 grams of the drug on the child's weight, but should not exceed 1 gram.The daily dose depends on the age of the child: children up to 1 year appoint 3 g, children 2-6 years - 3-6 bags;children 7-10 years of age may take the drug in an amount of 6-9 g;older than 10 years - 10-15 g

daily dose of aminocaproic acid for children is divided into 3-5 receptions.If

acute hypofibrinogenemia aminocaproic acid in solution form is administered at a dose of 100 ml by intravenous drip, repeated administration over 4 hours as needed.

aminocaproic acid in the nose

To prevent influenza aminocaproic acid is used in the nose, which is due to the ability of the drug to strengthen the blood vessels in the nasal sinuses, reducing the risk of bleeding and increase blood clotting.The process of the drug based on its anti-edema and anti-allergic effect, as well as the ability to reduce the amount of bleeding from the nose.Appointment of aminocaproic acid in the nose allows the interaction of the body and disrupt the virus.

recommended to use a 5% solution of aminocaproic acid as follows: 2-3 nasal drops 4 times a day for preventive purposes, and every 3 hours at treatment.Course - 3-7 days.Aminocaproic acid in the nose is not contraindicated for pregnant women (3 drops 3 times a day), but before use is necessary to consult a doctor.

Side effects

The instructions to the aminocaproic acid indicated the following negative consequences:

- fibrillation, bradycardia, subendocardial haemorrhage, orthostatic hypotension;

- diarrhea and nausea;convulsions, tinnitus, dizziness, headaches;

- skin rashes, acute renal failure, catarrhal phenomena of the upper respiratory tract.

Contraindications

Application aminocaproic acid inadmissible when:

  • tendency to thrombosis and embolism;
  • syndrome, disseminated intravascular coagulation;
  • hereditary thrombophilia and secondary;
  • gross hematuria;
  • hypersensitivity;
  • severe renal impairment;
  • breastfeeding;
  • pregnancy.

Additional information

Storage aminocaproic acid should be in a dry place at a temperature not exceeding 250C.Shelf life - 2 years.

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