23 September

Gepasol - Neo - instructions for use , indications, dosage

Gepasol-Neo - a preparation containing the amino acid solution for parenteral nutrition used in the treatment of liver failure.

release form and composition

Gepasol Neo-released in the form of a solution for infusions 8%: clear, from slightly yellow to colorless;with osmolarity - 770 mOsm / l, pH - 5,7-6,3 (in 500 ml glass vials, 1 bottle or a carton box 10 bottles in a carton).

in 1 liter of solution contains active substances: Glycine - 5.82 g;L-arginine - 10.72 g;L-histidine - 2.8 g;L-serine - 2.24 g;L-methionine - 1.1 g;L-proline - 5.73 g;L-isoleucine - 10.4 g;L-leucine - 13.09 g;L-valine - 10.08 g;L-phenylalanine - 0.88 g;L-lysine monoacetate, - 9.71 g of (L-lysine content - 6.88 g);L-Threonine - 4.4 g;L-alanine - 4.64 g;L-Tryptophan - 0.7 g;acetylcysteine ​​- 0.7 g (content of L-cysteine ​​- 0.52 g).

Auxiliary components: glacial acetic acid - 4,42 g / l;Water for injection - up to 1 liter.

solution Energy value - 320 kcal / l (1344 kJ / l).


  • treatment and parenteral
    nutrition (full or in part - with the addition of solutions of fat emulsions and carbohydrate) in the liver function disorders (liver failure) associated with impaired brain function (hepatic encephalopathy)and without it;
  • Treatment prekomatosnoe states and hepatic coma.


  • Hyperhydration;
  • Disturbances of amino acid metabolism;
  • hypokalemia;
  • Hyponatremia;
  • Heart failure (decompensation stage);
  • Renal failure (in patients with renal failure patients with hepatic coma is necessary to consider which of these states is more dangerous);
  • Pregnancy and lactation;
  • Age 18 years (safety and efficacy for patients in this age group have not been established);
  • hypersensitivity to the drug.

Dosage and Administration Dosage

Gepasol Neo-set individually.In appointing the drug is taken into account the concentration of ammonia in the blood and the degree of severity of the disease.

Gepasol Neo-administered intravenously.Speed ​​- 1,0-1,25 ml / kg body weight per hour (30-35 drops per minute), which corresponds to amino acids 0.08-0.1 g / kg per hour.The drug can be administered at a maximum rate - 1.25 ml / kg per hour.

maximum dose Gepasol-Neo - 18.75 ml / kg per day.

Typically, the drug is used until the complete disappearance of neurological symptoms.

Side effects When using

Gepasol Neo-recommended doses on the testimony of the side effects were identified.


It is advisable to apply Gepasol Neo-only indications given solely in medical hospitals .

During therapy need to periodically monitor the electrolyte and acid-base status, the degree of hydration of the body, the state of renal function.

Use only clear solution.Before use, make sure that the vial is not damaged.

Drug Interactions

There is information about the interaction of individual components Gepasol-Neo with theophylline, which can lead to an increase in clearance.

Because of the numerous data on the interaction in vitro to add other drugs to the solution Gepasol-Neo is not recommended.

Gepasol Neo-compatible with antibiotics such as: piperacillin, erythromycin, ceftriaxone, amikacin, ampicillin, cefotaxime, doxycycline, gentamicin, chloramphenicol, clindamycin, penicillin, netilmicin, tetracycline, tobramycin, and vancomycin.

Also, the drug can be used in conjunction with the following drugs: chlorpromazine, cyclophosphamide, aminophylline, cimetidine, digoxin, cytarabine, dopamine, famotidine, fluorouracil, phytomenadione, folic acid, heparin, methylprednisolone, methotrexate, furosemide, insulin, lidocaine, calcium gluconate,methyldopa, metoclopramide, propranolol, morphine, norepinephrine, nizatidine, and ranitidine riboflavin.

Terms and conditions of storage

Store at 15-25 ° C in the dark, out of reach of children.

Shelf life - 2 years.

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