24 September

Hydrocortisone - instruction , use, contraindications

Hydrocortisone - a hormone drug steroid nature, which is produced by the adrenal cortex and is involved in carbohydrate and protein metabolism.

Pharmacological group - steroids.

Formulation

The drug is available in the following forms:

  • Hydrocortisone eye ointment;
  • Hydrocortisone eye drops;
  • Hydrocortisone suspension for intramuscular and intra-articular injection;
  • powder for injection;
  • tablets Hydrocortisone;
  • Hydrocortisone Ointment;

active substance

Hydrocortisone

Pharmacological action

drug Hydrocortisone - a synthetic glucocorticosteroid agent for systemic and local use, with a strong high-speed anti-inflammatory, antiexudativ (decongestant), antisense (anti-allergic) immunosuppressive, antishock and antitoxic action.

Hydrocortisone through a certain chain reactions inhibits the release of inflammatory mediators.The immunosuppressive effect of the drug due to inhibition of the reactions of the immune system.

Indications Hydrocortisone

For topical use Hydrocortisone

Hydrocortisone Ointment with uninfected superficial skin surfaces.

For topical use eye drops and eye ointment Hydrocortisone in inflammatory processes in the anterior chamber of the eye without damaging the cornea:

  • uveitis;
  • keratitis;
  • iridocyclitis;
  • blepharitis;
  • allergic conjunctivitis, etc.

periarticular or intraarticular (Hydrocortisone Acetate in suspension):

  • posttraumatic osteoarthritis;.
  • carpal tunnel syndrome;
  • nonspecific tenosynovitis;
  • rheumatoid arthritis;
  • epicondylitis;
  • subacute and acute bursitis;
  • reactive synovitis.

intradermal injection (hydrocortisone acetate in suspension):

  • drug reaction;
  • lupus erythematosus;
  • atopic dermatitis (neurodermatitis);
  • granuloma annulare;
  • lichen planus and other

Systemic therapy (inside, in / m / w) hydrocortisone suspension, tablet, powder for injection:

  • endocrine disorders - hypercalcemia, as a result of the tumor process,
  • thyroiditis purulent.(thyrotoxic crisis), adrenal hyperplasia (congenital), adrenal insufficiency;
  • acute state of allergic reaction;
  • urgent conditions;
  • collagen;
  • skin diseases;
  • respiratory diseases such as pneumonitis respiratsionny (c-m Mendelssohn.) And others
  • hematologic disorders: aplastic anemia (congenital), erythroblastopenia, secondary thrombocytopenia, autoimmune anemia.
  • gastrointestinal diseases: b.Crohn's (in the complex therapy);
  • tuberculous meningitis (in combination with anti-tuberculosis chemotherapy);
  • trichinosis with myocardial damage or nervous system;
  • multiple sclerosis;
  • chlorine poisoning, organophosphorus compounds, vitamin D, quinine, acids, bites of snakes, spiders and insects.

Contraindications to the use of hydrocortisone

For external and topical use Hydrocortisone:

  • children up to 2 years,
  • individual hypersensitivity to the drug;
  • brief period after vaccination;
  • in violation of the integrity of the skin cover (ulcers, fractures, wounds) and ocular epithelium;
  • viral, fungal and bacterial diseases of the skin and eyes;
  • dermatitis near the mouth;
  • acne vulgaris acne vulgaris;
  • localization of facial rosacea;

wary recognize cases: pregnancy (I trimester) and lactation, systemic failure in tuberculosis, diabetes.

If systemic therapy hydrocortisone require caution:

  • severe hypertension;
  • syndrome Cushing's;
  • peptic ulcers;
  • diverticulitis;
  • osteoporosis;
  • postoperative period;
  • fungal diseases;
  • lactation and pregnancy;
  • acute endocarditis;
  • nephritis;
  • renal failure;
  • propensity to thromboembolism;
  • cold sores;
  • previous arthroplasty;
  • AIDS, HIV infection;
  • myasthenia gravis;
  • individual hypersensitivity to the drug.

Side effects

According to the instructions for the application of hydrocortisone Hydrocortisone possible occurrence of some undesirable side effects.

When applied topically, can develop allergies, burning, inektsirovanie vessels sclera;In the case of prolonged use Gidrokorizona drops or eye ointment Gidrokorizon may develop subcapsular cataracts, glaucoma and exophthalmos;

For external use can occur allergic skin reactions.

Local and general systemic side effects occur in the case of prolonged use of Hydrocortisone on very large surfaces or in areas of damaged skin, as well as when using Hydrocortisone Ointment under occlusive dressings.

When using hydrocortisone for systemic therapy, the following side effects:

part of the endocrine system:

  • decrease in carbohydrate tolerance;
  • hyperglycemia up to diabetes;
  • need to increase the dose of insulin or other hypoglycemic agents in diabetics;
  • growth retardation in children;
  • syndrome Cushing's;
  • pituitary-adrenal insufficiency;
  • dysmenorrhea;
  • hirsutism;
  • hormonal obesity;
  • cow atrophy of the adrenal glands - in the case of prolonged use of Hydrocortisone

From the musculoskeletal system:

  • osteoporosis with pathological fractures, compression fractures of the vertebrae;
  • aseptic necrosis of the humeral head and femur;
  • arthropathy;
  • arthralgia;
  • steroid myopathy;

part of the intestine:

  • perforation of the intestine;
  • gastric bleeding;
  • peptic ulcers;
  • pancreatitis;
  • dyspepsia;
  • esophagitis.

part of the skin and mucous membranes:

  • impaired wound healing,
  • allergic reactions
  • skin discoloration

CNS and organs of vision:

  • mental disorders;
  • subcapsular cataracts;
  • glaucoma;
  • increased intracranial pressure.

Other side effects: immunosuppressive conditions, violation of water-electrolyte metabolism, increased blood pressure, vasculitis.

Instructions for use Hydrocortisone

When emergencies recommend the use of hydrocortisone intravenously.

adult dose starts from 100 ml to 450-500 ml and more, depending on the severity of the patient's condition.Assign to 1500 mg / day.

/ m adults - 125-200mg per day

children - 15-30 mg per day, dividing the dose into several times.

intra-articular and periarticular Hydrocortisone administered in suspension:

  • adults to 3-50 mg;
  • children at 25 mg - 3 months.up to 1 year;25-50 mg - from 1 to 6 years old;at 50-75 mg - 6 to 14 years.

Hydrocortisone Ophthalmic Ointment is introduced into the conjunctival sac of 1, 2 or 3 times a day.

Hydrocortisone Ointment is applied in a thin layer on the skin no more than four times a day, a course of treatment is not more than three weeks.

According to the instructions of hydrocortisone, the initial dose for oral administration is 20-240ml, followed ёё decline.However, with exacerbation of multiple sclerosis, the dose may be increased to 800mg per day., Followed by reduction.

Storage

Store at room temperature.

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