12 August

Glibomet - instructions for use , indications, dosage

Glibomet - hypoglycemic drug for oral use.

release form and composition

Dosage Form: tablet round biconvex shape with a break line on one side coated white, odorless (20 pcs in blister packs in a cardboard unit 2, 3 or 5 blisters.).

content of active ingredients in 1 tablet:

  • glibenclamide - 2.5 mg;
  • Metformin hydrochloride - 400 mg.

Other ingredients: colloidal silicon dioxide, microcrystalline cellulose, glycerol, corn starch, magnesium stearate, gelatin, talc.

shell Ingredients: diethyl phthalate, acetylphthalyl, talc.


Use of the drug is indicated for the treatment of type 2 diabetes, in case of failure of previous therapy with biguanides, sulfonylureas or other oral hypoglycemic agents and dietary therapy.


  • Lactic acidosis, including a history;
  • type 1 diabetes;
  • State, accompanied by malabsorption of food and the development of hypoglycemia;
  • Diabetic ketoacidosis, diabetic coma and precoma;
  • Gestational diabetes mellitus;
  • Conditions that requ
    ire the use of insulin therapy, including gangrene, extensive burns, major surgery, acute blood loss volume, infectious disease, trauma;
  • Liver function disorders;
  • Renal failure or functional disorders of the kidneys;
  • Acute conditions that cause changes in renal function - severe infection, dehydration, intravascular administration of iodinated contrast agents, shock;
  • hypoxia on the background of pathological states - recent myocardial infarction, cardiac or respiratory failure, severe respiratory disease, shock;
  • Leukopenia;
  • Degenerative diseases, including myotonic dystrophy, lipodystrophy;
  • Porphyry;
  • period of 48 hours before and 48 hours after: surgery under general anesthesia with spinal or epidural anesthesia;radioisotope or radiological examinations, requiring introduction of iodine-containing contrast agent;
  • strict hypocaloric diet (1,000 kcal per day);
  • condition of acute alcohol intoxication, alcoholism;
  • the age of 18;
  • Age older than 60 years, in the case of performing hard physical activity (increased risk of lactic acidosis);
  • deficiency of glucose-6-phosphate dehydrogenase;
  • Pregnancy and breast-feeding;
  • hypersensitivity to the drug and sulfonylurea.

The caution is recommended to take the drug for diseases of the thyroid gland, a feverish syndrome, hypofunction of the adrenal cortex and / or the anterior pituitary.

Dosage and Administration

tablets are taken orally with meals.

dosage and period of treatment the doctor prescribes individually on the basis of clinical indications, given the concentration of glucose in the blood and the state of carbohydrate metabolism.

The initial dose is usually 1-3 tablets per day.During treatment the patient is selected dose effective to achieve a sustained normalization of blood glucose levels.

maximum daily dose should not exceed 6 tablets.

Side effects

  • Hematopoietic system: rarely - thrombocytopenia, leukopenia, erythropenia;very rarely - megaloblastic and hemolytic anemia, agranulocytosis, pancytopenia;
  • From the nervous system: rarely - headache;
  • part of the digestive system: rarely - loss of appetite, nausea, metal taste in the mouth, abdominal pain, vomiting, diarrhea;in some cases - increase in liver transaminases;
  • part of metabolism: rarely - hypoglycemia;very rarely - lactic acidosis;
  • For the skin: rarely - itching, rash, photosensitivity, erythema;
  • Other: against the backdrop of the simultaneous reception of alcohol - disulfiramopodobnyh reaction, with the characteristic features in the form of high blood pressure, headache, palpitations, flushing of the skin of the upper half of the body and face, nausea, vomiting.


necessary to stop taking the drug for symptoms of lactic acidosis as a general weakness, vomiting, abdominal pain, muscle cramps, and seek emergency medical attention.

The drug is recommended to be accompanied by regular monitoring of creatinine concentration in blood: in patients with normal renal function - at least 1 time per year in patients with serum creatinine concentration in the blood is close to the upper limit of normal, and the elderly - 2-4 times a year.

Glibomet should stop taking up to 2 days before elective surgery with anesthesia (spinal or epidural anesthesia).To continue receiving the drug allowed the resumption of oral nutrition, but not earlier than 2 days after the operation, if confirmed by the normal function of the kidneys.

During treatment is recommended to be careful when performing potentially hazardous activities and management of vehicles, because there is a possibility of hypoglycemia and, consequently, decrease the speed of psychomotor reactions and ability to concentrate.

effectiveness of the treatment depends on the strict adherence to doctor's appointments, his recommendations on the mode of physical activity and diet, regular monitoring of blood glucose levels.

When using Glibometa should refrain from drinking alcohol, t. To. Ethanol can be a cause of hypoglycemia and / or disulfiramopodobnyh reactions (abdominal pain, vomiting, nausea, sensation of heat in the upper body and face skin, dizziness, headache,tachycardia).

Drug Interactions

Action Glibometa increases while taking beta-blockers, derivatives of coumarin (warfarin sinkumar), allopurinol, cimetidine, monoamine oxidase inhibitors (MAOIs), oxytetracycline, sulfonamides, chloramphenicol, phenylbutazone and its derivatives, salicylates, probenecid, cyclophosphamide, perhexiline, sulfonamide feniramidola, sulfinpirazona, miconazole (for oral application) ethanol.

hypoglycemic effect of the drug lowers combination with corticosteroids, epinephrine, oral contraceptives, thiazide diuretics and barbiturates, drugs thyroid hormones.

parallel beta-blockers may mask the signs of hypoglycemia but excessive sweating.

Glibometa In an application with cimetidine increases the risk of lactic acidosis, with anticoagulants - there is a strengthening of their actions.

The risk of lactic acidosis increases the patient's X-ray examination with the use of intravascular iodinated contrast.

Terms and conditions of storage

Store at temperatures up to 30 ° C.Keep away from children.

Shelf life - 3 years.

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