Losap - pharmacological agents from the group of angiotensin II receptor antagonists used for the treatment of hypertension.
Losap release is available in tablets (dosage of 12.5 and 50 mg).The active ingredient - losartan.Lozap Tablets of instructions comprise the following auxiliary ingredients: microcrystalline cellulose, mannitol, colloidal silicon dioxide, crospovidone, talc, magnesium stearate, hypromellose, macrogol, titanium dioxide.
Lozap Tablets - oval, biconvex, film-coated.The drug is produced in blister packs of 10 tablets.The carton can be 3, 6 or 9, plastic blisters with instruction.
According to the instructions, Losap refers to the specific angiotensin II receptor antagonist and has a hypotensive effect.The drug reduces the total peripheral vascular resistance, lowers blood pressure, reduces stress on the heart muscle, reduces blood levels of adrenaline and aldosterone, has a diuretic effect.Losap increases exercise to
After a single dose of Lozap maximum antihypertensive effect develops after 6 hours and gradually decreases for 24 hours.With constant taking the drug the maximum antihypertensive effect occurs after 3-6 weeks from the beginning of the reception Lozap.
Application Lozap in patients with hypertension and proteinuria greater than 2 g / day significantly reduced protein loss in the urine excretion of albumin and immunoglobulins.At doses up to 150 mg per day Losap no effect on blood glucose (fasting) and lipid profile parameters.
Once inside Losap well absorbed, metabolized in the liver.Bioavailability of 33%.Withdrawal of the drug and its metabolites mainly through the intestines and kidneys.
Losap practically does not penetrate the blood-brain barrier.
Losap is used to treat hypertension.Also, the drug is shown as a part of complex treatment of patients with chronic heart failure patients with diabetic nephropathy (with hypercreatininemia and proteinuria).According to the instructions Losap can be used to reduce the risk of cardio - vascular complications in patients with hypertension and left ventricular hypertrophy.
Lozap contraindicated in such cases:
wary Losap used for violations of water-electrolyte metabolism, with bilateral renal artery stenosis, or renal artery stenosis of a solitary kidney, as well as signs of renal or hepatic insufficiency.
Clinical studies on the use of Lozap not carried out during pregnancy.It should be noted that the known fact that drugs which act on the angiotensin system aldosternovuyu have teratogenic effects (causing malformations and even fetal death).If the pregnancy is in the background of Lozap, it should be lifted immediately.During lactation, the drug is also not recommended for use.
This drug is taken orally 1 time a day, depending on the time of reception of eating the food there.
the treatment of hypertension Lozap average dose is 50 mg.If necessary, the dose may be increased to 100 mg.
In chronic heart failure is recommended to take Losap 12.5 mg per day.The dose may be increased (at weekly intervals) with good tolerability of the drug.
If a patient with congestive heart failure receiving high doses of diuretics (diuretics), then Lozap dose reduced to 25 mg per day.
Patients with impaired renal function, liver, as well as elderly patients recommended a lower initial dose of the drug (25 mg daily).
According to reviews Losap rarely causes side effects.If side effects occur, this condition is usually transient and discontinuation of therapy is required.The most frequent side effects Lozap the treatment of hypertension is dizziness (4.1%).Orthostatic effects Lozap on responses observed in less than 1% of patients.
remaining Lozap side effects do not differ from the side effects with placebo ( "dummy"), so their connection with the reception of this questionable drug.These adverse symptoms include: asthenia, fatigue, pain in the chest, limb swelling, palpitations, diarrhea, abdominal pain, nausea, pain in the back and / or legs, leg cramps, headache, insomnia, cough, nasal congestion.
case of overdose of this drug can be a marked decrease in blood pressure, tachycardia (sometimes bradycardia).Treatment consists in the appointment of symptomatic treatment, the use of forced diuresis.Hemodialysis in overdose Losap not effective.
According to the instructions, Losap can be combined with other antihypertensive drugs, it increases the effects of a one-and beta-sympatholytic adrenolokatorov.
a joint application Lozap and diuretics marked potentiation of the two drugs.
when taken concomitantly with digoxin, hydrochlorothiazide, warfarin, cimetidine, phenobarbital, erythromycin and ketoconazole pharmacologic interaction is detected.In the opinion of Losap well with these drugs without causing any symptoms.
Application Lozap with potassium-sparing diuretics (spironolactone, amiloride, triamterene) increases the risk of hyperkalemia.
begin use of this drug should be at a lower dose, as necessary to carry out the correction of water and electrolyte balance to the destination Lozap.
patients with liver cirrhosis the concentration of the drug in the blood increases, so to use it at lower doses.
recommended to monitor blood potassium concentration in the elderly and impaired renal function during therapy Losap.
According to the instructions, Losap does not affect the ability to drive and the ability to concentrate when working with moving machinery.
Lozap analogs are drugs from the same group of angiotensin II receptor antagonists, these include: Lorista, Vazotenz, Losartan, Prezartan, Cozaar, Bloktran, Renikard, Brozaar, Lozarel, Lothor.
Before replacing analogue Lozap should consult a doctor.These preparations are not intended for independent use.
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