5 October

Macropen - instructions for use , indications, dosage

Macropen - macrolide antibiotic, has bactericidal effect, in the low to high doses - bacteriostatic.

release form and composition

Dosage Forms:

  • tablets, film-coated: Round slightly biconvex shape with beveled edges and break line on one side, have a white color, on a break - rough white structure (8 pcs.in blisters in a carton box 2 blisters);
  • granules for suspension for oral administration: orange, fine, no visible impurities, with a slight scent of banana, an aqueous slurry has an orange color and a light banana flavor (20 g in glass bottles of dark color, in a cardboard bundle one bottle incomplete with a dosing spoon).

active substance macrofoams:

  • Tablets: midecamycin in 1 tablet - 400 mg;
  • Granules: midecamycin acetate, 5 ml of finished slurry - 175 mg.

Auxiliary components:

  • tablets: magnesium stearate, polacrilin potassium, microcrystalline cellulose, talc;
  • Granules: propyl parahydroxybenzoate, methyl parahydroxybenzoate, citric acid, sodium hydrogen phosphate anhydrous, sunset
    yellow dye FCF (E110), powder, banana flavor, mannitol, hypromellose, sodium saccharin, silicon defoamer.Additionally

shell consisting of tablets: macrogol, methacrylic acid copolymer, titanium dioxide, talc.

Indications

  • community-acquired pneumonia, chronic bronchitis (in the acute stage), acute otitis media, tonzillofaringit, sinusitis, including atypical respiratory tract infections caused by Chlamydia spp., Mycoplasma spp.,Ureaplasma urealyticum and Legionella spp .;
  • Prevention and treatment of whooping cough and diphtheria;
  • Infectious-inflammatory diseases of the genitourinary system caused by pathogens Legionella spp., Chlamydia spp., Ureaplasma urealyticum and Mycoplasma spp .;
  • Therapy enteritis caused by Campylobacter spp .;
  • Infectious diseases of the skin and subcutaneous tissue caused by microorganisms sensitive to the drug.

  • Contraindications Severe hepatic impairment;
  • period of breastfeeding;
  • hypersensitivity to the drug.

wary Macropen recommended to prescribe to patients with an indication of a history of hypersensitivity to acetylsalicylic acid.

During pregnancy, use of the drug is shown in an emergency, provided that the expected clinical benefit to the mother is much higher than the potential risk to the fetus.

The use of tablets is contraindicated under the age of 3 years.

Dosage and Administration

tablets and granules prepared from the suspension is taken orally before a meal.

slurry is prepared by dissolving the contents of a vial of 100 ml with distilled or boiled water.The suspension is suitable for use within 7 days of storage at room temperature and 14 days - when stored in the refrigerator.Before each reception suspension should be well shaken.

dose and the period of application assigns physician based on clinical indications.

Recommended dosage for tablets:

  • patients weighing more than 30 kg: 1 tablet 3 times a day, the daily dose for adults should not exceed 4 tablets;
  • children weighing up to 30 kg the daily dose designation made on the basis of 20-40 mg per 1 kg body weight with a multiplicity of receiving three times a day, or 50 mg per 1 kg of body weight in 2 hours.For treatment of severe infections: 50 mg per 1 kg of body weight in 3 divided doses.

daily dose for children is assigned a suspension rate of 50 mg per 1 kg of body weight of the child and taken in 2 hours using the measuring spoon.

single dose suspension has weight restrictions:

  • Children weighing up to 5 kg - 3.75 ml;
  • 5 to 10 kg - 7.5 ml;
  • 10 to 15 kg - 10 ml;
  • 15 to 20 kg - 15 ml;
  • 20 to 30 kg - 22.5 ml.

course of treatment is 7-14 days for chlamydial infections - 14 days.The daily dose

macrofoams diphtheria determined by the rate of 50 mg per 1 kg weight of the patient and is taken in 2 hours.The duration of treatment 7 days, then it is recommended to control bacteriological examination.

Prevention of pertussis is performed during the first 14 days after contact with an infected at a dose of 50 mg per 1 kg of body weight per day, course of treatment - 7-14 days.

Side effects

  • Allergic reactions: itching and rash, eosinophilia, urticaria, bronchospasm;
  • Digestive system: nausea, decreased appetite, vomiting, diarrhea, feeling of heaviness in the epigastric pain, stomatitis, elevated liver enzymes, jaundice;in some cases - a long and severe diarrhea, which is characteristic for the development of pseudomembranous colitis;
  • Other: weakness.

Cautions

macrofoams Application for a long time can lead to excessive growth of resistant bacteria and the development of pseudomembranous colitis, which is a strong sign of prolonged diarrhea.

Long-term therapy requires regular monitoring of liver enzymes, especially in patients with liver function disorders.

Mannitol, a part of the granules may cause diarrhea.

patients with hypersensitivity to acetylsalicylic acid should be aware of a history of the cause of allergic reactions, including bronchospasm, may be colorant sunset yellow (E110) as a part of the granules.

The drug does not affect the patient's ability to drive vehicles and mechanisms.

Drug Interactions

Use caution when combined with the drug carbamazepine and ergot alkaloids, since the action macrofoams reduces their rate of metabolism in the liver and increase the level of concentration in the blood serum.

Simultaneous treatment with cyclosporine, warfarin, and other anticoagulants slows their rate of excretion.

drug does not infringe the pharmacokinetics of theophylline.

Terms and conditions of storage

Keep away from children.

Store at temperatures up to 25 ° C, pills - in a dry place.

Shelf life - 3 years.

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