Monopril - angiotensin converting enzyme (ACE).
dosage form - tablets: round biconvex shape with a break line on one side and engraved "609" - on the other, can be almost white or white, without a specific smell (14 pcs in a blister.in a cardboard bundle 2 blisters).
Monoprix active substance - sodium fosinopril in 1 tablet - 20 mg.
Auxiliary ingredients: crospovidone, microcrystalline cellulose, anhydrous lactose, sodium fumarate, povidone.
With care should be prescribed Monopril patients with kidney failure, stenosis of the artery to a solitary kidney or bilateral renal artery stenosi
tablets are taken orally once a day 1.
dose sets the physician based on clinical indications.
recommended daily dosage Monoprix:
patients with functional disorders of the kidneys or liver, and elderly patients (65 years or older) Dose adjustment is not normally required.
Treatment is required to start after a thorough analysis of the degree of increase in blood pressure, previous antihypertensive therapy, reduction in liquid content of the diet and / or salt and other clinical factors.Previously held antihypertensive treatment, it is advisable to stop for a few days before the application of Monoprix.
To reduce the risk of hypotension, diuretics cancel 2-3 days prior to initiation of therapy.
use of the drug should be accompanied by regular monitoring of blood pressure, renal function, serum creatinine concentration of potassium ions, urea and electrolytes content in liver enzymes in the blood serum.
With the development of angioedema of the lips, face, tongue, larynx or pharynx, mucous membranes and extremities in patients receiving the drug should be discontinued Monopril.discontinuation of treatment often provides the normalization condition of the patient, if the swelling does not go, you must assign the appropriate therapy, including subcutaneous epinephrine solution (adrenaline) (1: 1000).Delayed aid can lead to airway obstruction with the risk of death.
In rare cases, ACE inhibitors can cause intestinal mucosal edema, accompanied by abdominal pain.Since it can occur without any signs of edema the person during normal activity of C1-esterase and absence of nausea or vomiting patient, it must be included in the differential diagnosis of patients complaining of abdominal pain.Symptoms of edema disappear after discontinuation of the drug.
patients with anaphylactic reactions to dialysis against using highly permeable membranes or low-density lipoprotein apheresis with dextran sulphate adsorption on the need to appoint another class antihypertensive drugs or using dialysis membranes of another type.
Due to the risk of anaphylactic reactions during desensitization of patients need to be especially careful.
To prevent the development of bone marrow suppression and agranulocytosis before ACE inhibitors and during therapy should be regularly (1 time per month during the first 3-6 months) to carry out certain leukocytes and leukocyte formula.In patients with increased risk (renal failure, systemic connective tissue disease) continue to conduct research in the first year of therapy.
Against dialysis, intensive care with diuretics, diet, limiting salt intake, the development of symptomatic hypotension occurs frequently.When transient hypotension continued use of the drug after the restoration of circulating blood volume.
The use of ACE inhibitors is indicated in patients with chronic heart failure, but it can cause excessive antihypertensive effect, potentiating the development of azotemia and oliguria, in rare cases - acute renal failure with fatal consequences.Therefore, each increasing the dose of the diuretic or Monoprix in this category of patients requires careful monitoring of their condition, especially during the first two weeks of therapy.Patients with hyponatremia, normal or low blood pressure, previously treated with diuretics may need to decrease the dose of the diuretic.
slight decrease in systemic blood pressure at the beginning of the treatment of patients with chronic heart failure is a typical and desirable effect.The maximum reduction in blood pressure is observed in the early stages of therapy and stabilized for 1-2 weeks without reducing the therapeutic effect.
In rare cases, ACE inhibitors can cause a syndrome that starts with cholestatic jaundice, followed by the onset of fulminant hepatic necrosis (with the risk of death).Since the nature of the syndrome has not been established, with a significant increase in liver enzymes in a patient and the occurrence of visible jaundice drug should be withdrawn and appropriate therapy.
If abnormal liver function can be observed in the blood plasma of the high content of fosinopril.In cirrhosis of the liver total clearance fozinoprilata, seemingly normal, is reduced, and the approximately 2-fold higher than the AUC, compared to patients with normal liver function.
When hypertension in patients with stenosis of the artery to a solitary kidney, or a single or bilateral renal artery stenosis ACE inhibitors may cause a reversible process of increasing the concentration of serum creatinine and blood urea nitrogen (in this case requires removal of the drug).This category of patients require regular monitoring of renal function in the first weeks of therapy.Increased serum concentrations of creatinine and blood urea nitrogen (usually minor and transient) in patients with normal renal function can be caused by the simultaneous reception and diuretics Monopril (in this case, a reduction in dose).
In severe chronic heart failure, ACE inhibitors may be associated with progressive azotemia and / or oliguria, in rare cases -Risks development of acute renal failure with fatal consequences.
a greater risk of hyperkalemia in patients receiving the drug exposed patients with type 1 diabetes mellitus, renal insufficiency, as well as taking kalisodergaszczye supplements, potassium-sparing diuretics, and other means to support increased levels of potassium ions in the blood serum.
In case of cough should be considered taking the drug as a possible cause in the differential diagnosis.
In preparation for surgery, the anesthesiologist must notify the admission of Monoprix.
Patients are advised to carefully perform physical activities, including in hot weather.
Due to the possible occurrence of dizziness, caution should be exercised in the management of vehicles and mechanisms.
During treatment Monoprilom simultaneous use of other medicines can be started only after consultation with your doctor, who can evaluate the interaction of drugs that will prevent the development of undesirable effects.
Store in a dry place inaccessible to children at a temperature of 15-25 ° C.
Shelf life - 2 years.
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