12 August

Nimesulide - instructions for use , indications, dosage

Nimesulide - a drug with anti-inflammatory and analgesic effect.

release form and composition

Nimesulide released in the form of tablets: oblong shape with rounded ends, biconvex, pale yellow with a faint greenish tinge, with Valium (in blisters of aluminum lacquered printed foil and PVC film of 10, 15,20, 30 pcs., for 1-6 packs per carton box).

The composition 1 tablet includes:

  • Active ingredient: Nimesulide - 100 mg;
  • Auxiliary components: microcrystalline cellulose - 66.8 mg Povidone - 14 mg, lactose monohydrate - 68 mg Potato starch - 68 mg sodium carboxymethyl starch (sodium starch glycolate) - 36 mg Talc - 3.6 mg magnesium stearate- 3.6 mg.


Nimesulide is prescribed for acute pain, osteoarthritis pain syndrome (symptomatic treatment), primary dysmenorrhea.

Contraindications Absolute:

  • erosive and ulcerative lesions of the gastrointestinal tract (during exacerbation);
  • Severe blood coagulation;
  • Gastrointestinal bleeding or any other conditions that are accompan
    ied by bleeding;
  • severe heart failure;
  • Cerebrovascular hemorrhage;
  • expressed functional renal impairment (with creatinine clearance less than 30 mL per minute);
  • Liver function disorders;
  • Drug addiction;
  • Alcoholism;
  • intolerance to nonsteroidal anti-inflammatory drugs;
  • Concomitant use with other hepatotoxic drugs;
  • Pregnancy and lactation;
  • Children under the age of 12 years;
  • hypersensitivity to the drug.

Relative (Nimesulide should be used with caution in the presence of the following diseases / conditions):

  • Infectious Diseases;
  • diseases of the gastrointestinal tract (including history);
  • Hypertension;
  • cardiac and renal failure;
  • Type 2 diabetes;
  • hemorrhagic diathesis;
  • Severe metabolic disorders;
  • asthenia (exhaustion, fatigue);
  • Dehydration;
  • elderly.

Dosage and Administration

Nimesulide is taken orally, preferably - after eating, drinking plenty of water.

Recommended dosing regimens:

  • Adults: 2 times daily 1 tablet (100 mg);maximum - 400 mg per day;
  • Children from 12 years old with a body weight greater than 40 kg: 2 times daily 1 tablet (100 mg);maximum - 200 mg per day;
  • Children from 12 years old with a body weight less than 40 kg: a single dose - 1.5 mg / kg body weight, the multiplicity of reception - 2-3 times a day;the maximum daily dose - 5 mg / kg.

should take the lowest effective dose of nimesulide.Duration of therapy should not exceed 15 days.

Elderly patients Dose adjustment is not required.

Side effects

When using nimesulide can be observed violations of some body systems that appear with varying frequency (≥1 / 10 - very often; & gt; 1/100, & lt; 1/10 - often; & gt; 1 /1000, & lt; 1/100 - infrequently; & gt; 1/10 000, & lt; 1/1000 - rarely; & lt; 1/10 000, including isolated reports - very rare):

  • nervous system: infrequent - dizziness;rarely - irritability, sleep disturbances, anxiety;very rarely - encephalopathy, headache, Raynaud's syndrome, drowsiness;
  • Cardiovascular system: Infrequent - hypertension;rarely - palpitations, tachycardia;
  • Gastrointestinal tract: often - indigestion, vomiting, nausea, diarrhea;infrequently - bloating, constipation, gastritis;very rarely - ulceration of the mucosa of the gastrointestinal tract, stomach pain, melena, tarry stools, increased activity of hepatic transaminases, toxic hepatitis (including fatal);
  • Kidneys and urinary tract: rarely - hematuria, dysuria, fluid retention;very rarely - renal failure, oliguria, interstitial nephritis;
  • Blood and lymphatic system: rarely - eosinophilia, anemia, prolonged bleeding;very rarely - agranulocytosis, thrombocytopenia, purpura, pancytopenia;
  • Allergic reactions: seldom - skin rash and itching;rare - rash, erythema;very rarely - severe skin effects, including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, anaphylactic shock, bronchospasm;
  • Other: rarely - swelling;rarely - hyperkalemia, fatigue, vertigo, blurred vision, malaise;very rarely - hypothermia.

With the development of any of the above side effects, as well as in cases of other disorders should consult a physician.


With the development of symptoms during therapy, indicating liver damage (in the form of anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine) or abnormal results of liver function samples Nimesulide to cancel.Such patients are not recommended to take the drug in the future.

Gastrointestinal bleeding or perforation / ulcer during treatment can occur at any time, with the appearance of warning signs and the presence of gastrointestinal complications of history, or without them.With the development of ulcers or gastrointestinal bleeding the drug you want to cancel.

During treatment with nimesulide are advised to avoid the use of ethanol, as well as the simultaneous application of hepatotoxic drugs, analgesics and other nonsteroidal anti-inflammatory agents.

At deterioration of renal function is necessary to interrupt treatment.

Patients with hemorrhagic diathesis Nimesulide should be used under constant supervision.

Most often the development of side effects (including perforation, gastrointestinal bleeding, cardiac, liver and kidney) was observed in elderly patients, so patients in this age group need regular clinical control of the state.

While formulations of nimesulide should be careful with the road management, maintenance of moving parts and carrying out other potentially hazardous work requiring increased attention and rapid psychomotor reactions, which is associated with the probability of side effects as dizziness and sleepiness.

Drug Interactions

With simultaneous application of nimesulide with some drugs may cause the following effects:

  • drugs metabolized with the participation of the enzyme SYP2S9: increasing their concentration in plasma;
  • Cyclosporine: increased nephrotoxicity;
  • antiepileptic (valproic acid), antifungals (ketoconazole), anti-TB drugs (isoniazid), amiodarone, methotrexate, methyldopa, amoxicillin: the development of the additive hepatotoxic effects;
  • Warfarin similar anticoagulants, acetylsalicylic acid: increased risk of bleeding (the combination is not recommended for severe blood clotting disorders - contraindicated, concurrent use of these drugs, if necessary, need to monitor the effects of anticoagulants);
  • Furosemide: reducing its effectiveness (care should be taken against the background of functional disorders of the heart and kidneys);
  • lithium preparations: increase the concentration of lithium in blood plasma and its toxicity (requires regular monitoring of its concentration).

Terms and conditions of storage

Store in a dark, dry place inaccessible to children at temperature up to 25 ° C.

Shelf life - 2 years.

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