Orlistat - lipid-lowering agent for the treatment of obesity.
The active ingredient of the drug blocks the intestine and the stomach enzymes that break down fats (lipase).Thus it becomes impossible to disintegration of complex fats into fatty acids and monoglycerides, and they are not absorbed from the gut and are output unchanged.The components of the digestion of fat is not absorbed into the blood when taking orlistat, that is in the body creates a calorie deficit, which is why he is starting to lose your own deposited as excess fat tissue.
The received dose of the drug exerts its activity without causing systemic effects on the entire body.The therapeutic dose of orlistat blocks about 30% of the digestion of fats.
According to studies, the drug has no negative impact on the composition and properties of bile, the rate of advancement of the food bolus through the digestive tract and gastric acidity.The effect of increasing doses above the therapeutic was ins
There is a clear link between obesity and the presence of cardiovascular disease, type 2 diabetes, gallstone disease, some forms of cancer.By reducing body weight in obese patients orlistat prevents the occurrence of such conditions and mortality.
According to the observations, after 24-48 hours after the start of treatment in the stool increased fat content.After the abolition of orlistat reduced fat in the stool to normal within 2-3 days.
drug is hardly absorbed from the digestive tract into the body, it is converted in small amounts in two inactive metabolites, but 83% of its output in the faeces in the unaltered state.Orlistat does not possess carcinogenic, embryotoxic, mutagenic.
According to instructions issued Orlistat capsules blue on 120 mg.
conjunction with a low calorie diet, orlistat is used according to the instructions for obesity and to reduce excess body weight.The product is also suitable for reducing the likelihood of repeated weight gain after the initial reduction.The values of body mass index regulate the appointment of orlistat for obesity with a BMI ≥30 kg / m2, and even at the figures BMI ≥27 kg / m2, and the presence of risk factors (hypertension, diabetes, and others.).
Contraindications Orlistat is not applicable in case of hypersensitivity to the drug, with cholestasis (bile stasis) and chronic malabsorption in the small intestine (malabsorption).
Due to the lack of research on the safety and efficacy of the drug in children, lactating and pregnant women, its use is limited.Precautions should be taken in the presence of orlistat and calcium oxalate kidney stones, hyperoxaluria history.
According to the instructions the drug should be taken with food, not later than 1 hour after the meal.Dosage corresponds to 120 mg three times a day.By increasing the therapeutic dosage of orlistat on responses to a certain level rise and its lipid-lowering effect.If for some reason missed meal, or it lacks fats permitted skipping one dose.
patients with concomitant diabetes mellitus with weight loss in patients receiving orlistat may need to reduce the dose of antidiabetic drugs.
orlistat can cause a number of adverse reactions:
If you do not follow a low-calorie diet, the number of adverse reactions from the digestive tract to increase during treatment.
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