Tolterodine - a substance that is a competitive blocker of m-cholinergic receptors, and which is part of the drugs used in the treatment of urological diseases.
Included in the various drugs tolterodine compound is an antagonist of m-cholinergic receptors, which are localized in the salivary glands and bladder, has holinoliticheskoe and antispasmodic action.
active 5-hydroxymethyl derivative of tolterodine is highly specific for muscarinic receptors, has no effect on the other receptors, and has, in contrast to the receptors of the salivary glands, the selectivity for receptors of the bladder.
tolterodine According to the instructions included with antispasmodic drugs, not only reduces the activity of the bladder, but also reduces the detrusor pressure and salivation, contributes to the weakening and disappearance of incontinence and increase the interval between urination.
release tolterodine According to the instructions included in
Detruzitol, Urotol Debye- and are analogues of tolterodine-containing regimens for the active substance.For analogs containing tolterodine drugs mechanism of action and of belonging to the same pharmacological group includes medications:
According to the instructions prescribed in the treatment of overactive bladder, which manifests itself in the form of urinary incontinence or frequent mandatory urination.
in accordance with the instructions containing tolterodine medications taken orally to 2 mg twice a day.In the presence of hepatic or renal insufficiency in a patient, and the development of side effects, the dose was reduced by half (1 mg twice a day).The length of treatment formulations containing tolterodine, ranging from three to six months.
In accordance with the instruction of tolterodine is contraindicated in case of hypersensitivity to the substance, urinary retention, intractable treatment of myasthenia gravis, angle-closure glaucoma, severe ulcerative colitis and megacolon.
use of drugs, which include tolterodine substance of reviews is side effects of the various systems of the body, namely:
Also, drugs containing tolterodine on responses cause allergic reactions and flu-like symptoms, weight gain, sinusitis, bronchitis and skin dryness.
combined use of tolterodine with anticholinergics enhances the therapeutic effects of the drug and increases the risk of side effects.The combined use of tolterodine with muscarinic cholinergic receptor agonist reduces the effect of the substance.
In parallel with the use of tolterodine fluoxetine observed significant inhibition of the metabolism of tolterodine in extensive metabolizantov.
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