12 October

Femara - instructions for use , real counterparts , dose

Femara - is a drug belonging to the group of antagonists of hormones and hormonal anticancer agents.It is used for the treatment of malignant breast tumors.Pharmacological action

Femara Femara has a marked anti-estrogen action by blocking estrogen synthesis, both in tumor tissue and in peripheral tissues.The daily intake of the drug helps to reduce concentrations of estrone sulfate, estrone and estradiol in the blood of patients by 75 - 95% from baseline.

The instructions to Femara noted that taking the drug at therapeutic doses does not lead to a violation of the synthesis of adrenal steroid hormones.Therefore, this drug does not require additional purpose mineralocorticoids and glucocorticoids.

Femara does not change the content in the blood plasma concentrations of follicle-stimulating and luteinizing hormones, does not cause thyroid dysfunction, and does not increase the risk of stroke, myocardial infarction, and osteoporosis.

Feedback from Femara applied for adjuvant (secondary) treatment of

early stage breast cancer significantly reduces the risk of further disease progression and increases the five-year survival rate of patients with no signs of disease.Femara reduces by 40% the mortality rate among patients who have been sucked the lymph nodes in the pathological process.

Femara is rapidly absorbed from the gastrointestinal tract.Food intake does not affect the bioavailability.The maximum blood levels achieved after 1 - 2 hours after taking the tablets.

Write mainly as metabolites in the kidneys.Only a small portion of the drug is excreted through the intestines.

Indications The drug is used for the adjuvant treatment of early stages of malignant tumors of the mammary glands in females are postmenopausal (natural or artificially induced).Femara also can be used for first-line therapy in postmenopausal women with hormone-dependent common form of breast cancer.

There are numerous analogues Femara, which have exactly the same testimony.

Instructions for use

The drug is recommended to take 1 tablet (2.5 mg) once a day for a very long time.Extended adjuvant treatment can last up to five years.

If there are signs of progression, the treatment should be discontinued immediately.

Femara tablets can be taken at any time of the day and regardless of the meal.

  • Contraindications Pregnancy and lactation;
  • childhood and adolescence;
  • Endocrine status of women in reproductive period.

Pregnancy and lactation

Femara is strictly contraindicated during pregnancy and lactation.Therefore, when using this tool in women are perimenopausal or early postmenopausal period should encourage them to reliable methods of contraception.

Side effects

Femara Femara On responses can lead to adverse reactions from the various organs and systems:

  • digestive tract - dyspepsia, nausea, vomiting, diarrhea or constipation, stomatitis, increased transaminases;
  • Nervous system - dizziness, headache, nervousness, irritability, depression, transient ischemic attacks;
  • hematopoietic system - the development of leukopenia;
  • Cardiovascular system - tachycardia, increased blood pressure, thrombophlebitis;
  • Dermatological reactions - skin rash, itching, sweating, alopecia, angioedema,
  • Musculoskeletal - myalgia, arthralgia, osteoporosis.

Feedback from Femara very often leads to the tides (paroxysmal hot flashes), fatigue, weight gain.

Cautions

Femara should be administered with caution to patients suffering from severe hepatic impairment.Some side effects of this drug (dizziness, weakness, etc.) can affect the performance of work requiring quick response and high concentration.

Overdose In case of accidental or deliberate taking a large dose of the drug Femara should immediately seek medical attention.Specific antidotes are not known, therefore, is supportive and symptomatic therapy for the treatment of poisoning.The instructions to Femara noted that accelerate the withdrawal from the body of patients with the drug may be using hemodialysis.

composition, the release form and packaging Femara

Femara is available in tablets having a lenticular shape and film-coated yellow.On one side of the printed tablets «CG», and on the other - «FV».

Each tablet contains 2.5 mg of active substance.As auxiliary substances are used: titanium dioxide, iron oxide yellow dye, macrogol 8000, talc, Hypromellose, magnesium stearate, colloidal silicon dioxide, sodium carboxymethylstarch, corn starch, microcrystalline cellulose, lactose monohydrate.

tablets packed in blisters of 10 pieces.One carton box - 3 blisters.

Analogs Femara

Currently pharmacies sold medicines, similar in its effect to Femara.These include: Etruzil, Ekstraza, yelling, Neksazol, Letrotera, Letrosan, Letrozole-Teva, Letroza, Letrodeks.Despite the fact that all analogues of Femara in fact have the same pharmacological action is better to take just the drug that is assigned to you by your doctor.In case of his absence in the pharmacy network, consult with a specialist on the subject of possible replacement.

Terms and Conditions of storage

Femara belongs to the B list and released from pharmacies only by prescription.The drug should be stored in a cool dry place out of reach of children.Shelf life - five years.After the expiration date medication use is prohibited.

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