12 October

Fentanyl - instructions for use , the release form

Fentanyl - a drug belonging to the group of opioid analgesics.

Pharmacological action Fentanyl

Fentanyl is a synthetic analgesic with a short and fast analgesic and sedative effects.In its analgesic capacity many times greater than morphine.

drug has a depressing effect on the vasomotor and respiratory centers.Turn the vomiting center, as well as centers of the vagus nerve.Fentanyl increases the tone of the sphincter of the urinary and gall bladder.Decreases renal blood flow, intestinal motility, and blood pressure.Promotes the onset of physiological sleep, it causes euphoria.

rate of development of tolerance and drug dependence to the analgesic effect of Fentanyl differs considerable individual differences.

drug is significantly less likely to cause histamine reactions than other opioid analgesics.

The instructions to fentanyl noted that the maximum analgesic effect of intravenous administration of the drug observed after 3 minutes, and intramuscular - in half an hour.Its duration of action when

administered intravenously is one hour, intramuscular - 2 hours using a transdermal therapeutic system (TTS) - up to 72 hours.

Indications

Fentanyl is used in injections:

  • For the relief of pain (post-operative pain, trauma, cancer patients, myocardial infarction);
  • For the sedation;
  • For the neyroleptanalgezii.

Product form a Fentanyl transdermal therapeutic system (TTS) is intended for the treatment of chronic pain resulting from cancer pathology and certain other diseases (infection Varicella zoster, neuropathy, etc.).

Contraindications

  • oppression of the respiratory center;
  • Hypersensitivity;
  • Bronchial asthma;
  • Pregnancy and lactation;
  • obstetric operations;
  • Brain hypertension;
  • Addiction.

Side effects

Fentanyl Fentanyl According to the instructions can lead to side effects of the different systems:

  • Respiratory - respiratory depression until it stops;
  • central nervous system and sensory organs - drowsiness, headache, blurred vision, euphoria, increased intracranial pressure;
  • digestive system - nausea, vomiting, constipation, biliary colic;
  • Cardiovascular system - decreased blood pressure, bradycardia up to cardiac arrest;
  • Urinary system - urinary retention;
  • Allergic reactions - itching, chills, laryngospasm, bronchospasm.

release form Fentanyl as a patch can lead to applications in place burning sensation, itching, redness of the skin.These phenomena disappear within one day after removal of the patch.

Receiving Fentanyl may lead to drug dependence.

Fentanyl Overdose

case of overdose of the drug needed emergency medical care.Fentanyl is a specific antidote Naloxone.Is supportive and symptomatic therapy (translation on a ventilator, atropine sulfate, filling the BCC).

Dosage Fentanyl

According to the instructions to fentanyl, depending on the clinical situation is assigned to intravenous or intramuscular administration of the drug at a dose of 2.5 to 150 mg per kg of patient body weight.Intervals between doses are determined individually by your doctor.

When using TTS dose depends on the patient's condition and the effectiveness of this method of treatment.

Cautions

According to the instructions Fentanyl should only be used by medical personnel, ready to be held in case of need resuscitation.

When using the patch should avoid sun exposure, use of the sauna.

During treatment, patients are prohibited from engaging performing work which requires high concentration of attention and speed of reaction.

Prohibited conduct neyroleptanalgezii in the absence of the necessary equipment for ventilation.

Product form

Fentanyl Injection is available in the form of a 0.005% solution in ampoules of 2.0 and 5.0 ml.

Fentanyl is also included in the TTS having a kind of plaster with a special membrane that regulates the release rate of the active substance.

storage

Fentanyl belongs to the list of conditions A and must be kept by the rules established for the storage of narcotic drugs.

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