12 August

Cinnarizine - instructions for use , indications, reviews

Cinnarizine - drug mainly used to treat a variety of disorders of cerebral circulation.

Pharmacological action

Cinnarizine reduces the content of calcium ions into cells, relaxes muscles of arterioles, as well as enhances the vasodilatory action of carbon dioxide.

This drug not only affects the state of the tone of the vascular wall, but also reduces the vascular reactivity response to dopamine, angiotensin, epinephrine, norepinephrine and vasopressin.Application

cinnarizine enhances lumen of blood vessels, including the brain.This is not observed in blood pressure reduction.

addition, the drug reduces the excitability of the vestibular apparatus, suppresses nystagmus, lowers the tone of the sympathetic nervous system, increases the resistance of tissues to hypoxia and reduces blood viscosity.

Cinnarizine also has an average antihistamine activity.

drug is rapidly absorbed from the digestive tract and by 91% bound to plasma proteins.Its maximum concentration in the blood reached after 2 - 3 hou

rs after dosing.

not teratogenic.

Product form

Cinnarizine release tablets, each containing 25 mg of active substance in a package of 50 pieces in the form of drops in bottles of 20.0 ml, containing 75 mg of cinnarizine.

analogs of this drug are stugeron, Tsinnaron, Tsinedil, Vertizin.

Indications Cinnarizinum

This drug is widely used in medical practice.Indications Cinnarizinum following:

  • Various circulatory disorders in the brain (atherosclerosis, ischemic stroke, after suffering traumatic brain injury and hemorrhagic stroke, encephalopathy);
  • Nausea, vomiting and tinnitus labyrinth of origin;
  • Meniere's disease;
  • Nystagmus;
  • Violations of thinking;
  • Reduction and memory loss;
  • senile dementia;
  • Inability to concentrate;
  • Peripheral circulatory disorders (thrombophlebitis, Raynaud's disease, diabetic angiopathy, trophic ulcers, "intermittent" claudication syndrome);
  • Prophylaxis of migraine attacks;
  • Prevention kinetoses (sea and air sickness).

Another indication for Cinnarizine is a symptomatic therapy of cerebrovascular pathologies that manifest bouts of dizziness, headaches, irritability, tinnitus.


When violations of cerebral circulation appoint three to six tablets a day.

At various violations of the peripheral circulation is assigned from 150 to 225 mg of cinnarizine per day, ie,from six to nine tablets.

When vestibular disorders Cinnarizinum manual recommends taking it to three tablets a day.

On reviews Cinnarizine is a good tool for the prevention of motion sickness.For 30 minutes prior to departure, the trip or the flight should take one tablet (25 mg).If need be, then 6 hours after the dose may be repeated once more.Babies this give half the adult dose.

If the patient is not very well tolerated by Cinnarizine, he begin treatment with half the dose and gradually increase it until the therapeutic.

Side effects of cinnarizine

According to the instructions Cinnarizine may have the following side effects:

  • Headache;
  • Drowsiness;
  • Depression;
  • Extrapyramidal disorders;
  • Fatigue;
  • Dry mouth;
  • Pain in epigastric;
  • cholestatic jaundice;
  • dyspeptic symptoms;
  • Weight gain;
  • skin rash;
  • Allergic reactions.

On reviews Cinnarizine very rarely can lead to limb tremor and improve muscle tone.


According Tsinnarizinprotivopokazan instructions in case of hypersensitivity to the drug or nursing mothers.

With caution the drug must be administered to people suffering from Parkinson's disease.

When pregnancy indications for use of cinnarizine should be very carefully evaluated by a doctor.Although repeatedly conducted tests teratogenic effect of the drug has not been proven, it is still recommended to use only in the event that the anticipated benefits of therapy outweighs the potential risk.


Cinnarizine enhances the action of vasodilators, antihypertensives, sedatives and alcohol.Reduces the effectiveness of drugs for the treatment of arterial hypotension.

On reviews Cinnarizine significantly increases the efficiency at the same time used to it nootropnyhlekarstvennyh drugs.

Overdose In case of accidental or deliberate acceptance inside large dose Cinnarizinum performed gastric lavage and give activated charcoal.Further treatment is symptomatic, becauseNo specific antidote.


By instruktsiiTsinnarizindolzhen carefully appointed drivers and others whose occupations require high concentration of attention, becauseat the beginning of the treatment is often marked drowsiness.

With prolonged use of cinnarizine is necessary to control the picture of peripheral blood, kidney and liver function.

In appointing the drug athletes must take into account that it has an impact on the results of doping control.

storage Cinnarizinum

Terms Tsinnarizinotnositsya to the list B. It was stored at room temperature, protected from light.

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