12 August

Tsipraleks - instructions for use , treatment , analogs

Tsipraleks - preparation of the antidepressant group, whose mechanism of action is the selective inhibition of serotonin reuptake.This leads to an increase in the content of this neurotransmitter in the synaptic cleft substance, amplification and prolongation of its action on postsynaptic receptor sites in the area.The composition includes the active ingredient Tsipraleksa - escitalopram, which has very high selectivity, i.e. virtually not bind to other receptors, including serotonin 5-NT1A- 5-NT2-, dopamine, adrenergic, histamine H1-M-cholinergic receptors.benzodiazepine and opioid receptors.Because of these properties Tsipraleksom treatment of depressive syndromes is very effective.The drug is widely used in the mental practice and the positive feedback on Tsipralekse talk about high activity of the drug.


Tsipraleks release preparation in the form of film-coated tablets containing 5, 10, 20 mg of the active ingredient.

Indications Tsipraleks

preparation According to the instructions

, Tsipraleks applied under the following conditions:

  • depressive episodes, regardless of severity;
  • panic disorder with or without agoraphobia.

Contraindications Tsipraleks

drug Tsipraleksu The instructions to indicate the following contraindications to the use of this drug:

  • Hypersensitivity to the active substance and the auxiliary components included in the composition of the drug;
  • simultaneous reception of preparations of MAO inhibitors;
  • pregnancy;
  • lactation;
  • age of 15 years.

Use during pregnancy and lactation

Tsipraleksom Treatment during pregnancy and lactation is contraindicated.When using SSRIs during pregnancy have been observed in newborns psychophysical symptoms indicative of serotonergic effect, as well as the occurrence of withdrawal syndrome.Therefore, in the case of using analog or Tsipraleksa pregnancy their use should not be interrupted rapidly.

Side effects

Tsipraleksa When applied according to instructions side effects occur rarely, usually in the first week of therapy, and then their intensity is greatly reduced.You may experience the following side effects:

  • of the digestive system may cause nausea, diarrhea, loss of appetite, constipation, vomiting, dry mouth, disturbances of function of the liver;
  • of the nervous system: dizziness, insomnia or drowsiness, visual disturbances, tremor, seizures, disorders of motor activity, taste sensations, hallucinations, confusion, mania, serotonin syndrome, agitation, depersonalization, anxiety, panic attacks;
  • on the part of the reproductive system: in men may reduce libido, ejaculation disorder, impotence, female - anorgasmia;
  • from the vascular system may develop orthostatic hypotension;
  • on the part of the endocrine system: galactorrhea, inadequate secretion of ADH;
  • other side effects may develop anaphylactic reaction, skin rash, pruritus, purpura, ecchymosis, arthralgia, myalgia, urinary retention.

These phenomena are often the cause of the negative reviews about Tsipralekse from patients, but pretty quickly cease at the correct use of the drug side effects.

Treatment Tsipraleksom need to stop smoothly as possible the development of withdrawal symptoms: nausea, dizziness, headache.


Symptoms of overdose Tsipraleksa are dizziness, agitation, tremors, drowsiness, impaired consciousness, seizures, ECG changes (changes in the T wave, the segment ST, the expansion of the QRS, elongation QT), arrhythmia, respiratory distress, vomiting, metabolic acidosis, rhabdomyolysis, hypokalemia.

Tsipraleksom case of overdose symptomatic and supportive therapy, as a specific antidote exists.Conducted intensive gastric lavage, requires an adequate oxygen supply, monitoring the activities of the respiratory and cardiovascular systems.

Dosing and dosage of the drug Tsipraleks

According to the instructions, Tsipraleks administered orally, regardless of food intake, the daily dose - at one time.

If depressive episodes therapeutic dose is 10, a maximum of 20 mg per day.

Tsipraleksa antidepressant effect develops after 2-4 weeks of starting treatment.After a therapeutic effect Tsipraleksom treatment should continue for at least 6 months.

for panic disorder is recommended the following regimen Tsipraleksa and analogues: the dosage of the first week of treatment - 5 mg, then increased to 10 mg.The maximum daily dosage Tsipraleksa - 20mg.

therapeutic effect in this pathology develops within 3 months.Tsipraleksom treatment in this situation should also continue for several months.

recommended daily dosage Tsipraleksa for elderly patients half.

patients with kidney disease and liver (mild to moderate) dose adjustment is not necessary.However, with a decrease in creatinine clearance less than 30 ml / min use Tsipraleks and analogues should be with caution.

In order to prevent the development of withdrawal is necessary to reduce the dosage gradually Tsipraleksa, within two weeks.

interaction with other drugs

When using Tsipraleksa and MAO inhibitors significantly increased risk of serotonin syndrome.It's possible complication while taking serotonergic drugs.Possible increased risk of seizures, while the application Tsipraleksa and drugs that reduce the seizure threshold.Tsipraleks increases the effect of drugs that reduce blood clotting, so, while the appointment of these drugs requires constant monitoring of hemogram.Tsipraleks increases blood levels of drugs such as desipramine, and metoprolol.


Due to the high efficiency reviews of Tsipralekse good enough.The drug significantly reduces the symptoms of neuropsychiatric disorders with depressive syndrome.However, the drug has many side effects, so you need to carefully study the instructions in the Tsipraleksu before use of the drug.


Currently in pharmacies meet the following analogues Tsipraleksa: Lenuksin, Miratsitol, Santsipam, selectors, Elitseya, Escitalopram-Teva.

Storage Tsipraleks drug refers to the list B. Tsipraleks should be stored at room temperature out of reach of children.Sold exclusively by prescription.

Use this drug can only be prescribed by a doctor for.

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