12 August

Cipramil - instructions for use , real counterparts

International name: citalopram.

Ingredients Active ingredient - citalopram hydrobromide.As auxiliary substances are used: 85% glycerol, corn starch, croscarmellose sodium, lactose monohydrate, microcrystalline cellulose, copovidone, magnesium stearate.

Sheath: macrogol 400, gipromelloza5, titanium dioxide (E 171).

Pharmacological Effects Cipramil Cipramil

- antidepressant, selective serotonin reuptake inhibitor.

Cipramil has a very mild ability to bind to receptors, including muscarinic, histamine and adrenergic receptors.

Cipramil to a very small extent inhibits cytochrome P450IID6 and thus does not interact with drugs metabolized by this enzyme.Cipramil no effect on blood pressure, on the conducting system of the heart, on hematological parameters, as well as liver and kidney function.Antidepressant effect tsipramil develops in about 2-4 weeks of regular admission.Acceptance of the drug does not contribute to weight gain.

After the internal application of the drug bioavailability of

citalopram is about 80%.The level of maximum plasma concentration achieved poproshestvii 2-4 hours after ingestion.Metabolism occurs through demethylation and oxidation deamination.Steady blood plasma concentration is set within 1-2 weeks of regular treatment.The half-life is 36 hours.Return with urine and feces.


Cipramil is used to treat depression and etiology of various structures in adult patients and in the treatment of panic disorder and obsessive-kompulsivnyhrasstroystv.


Cipramil is contraindicated in persons with hypersensitivity to citalopram or to any of the excipients used.

tsipramil should be avoided in combination with monoamine oxidase inhibitors, including within 14 days after completion of reception.According to the instructions

Cipramil therapy for pregnant and lactating women is possible only on the basis of comparing the likely benefit for the mother with the likely harm to the child.Safety Research tsipramil receive during pregnancy and lactation was conducted.

tsipramil Dosage and method of administration

drug is administered once at any time, regardless of the meal.

the treatment of depression: prescribe 20 mg per day.If necessary, the dose may be increased to 60 mg / day.In therapy

panic disorder, during the first week prescribed 10 mg per day, then the dose increased to 20 mg.If necessary, the dose may be increased to 60 mg / day.

Patients over 65 years recommended dose is 20 mg per day, with a possible increase to 40 mg per day.Patients with hepatic impairment is recommended to take the drug in small doses, the maximum dose of 30 mg per day.In mild and moderate renal insufficiency does not require dose adjustment.

Side Effects Cipramil

Side effects of the drug wear transistor and bland character may occur in the first weeks of treatment, with the improvement of the patient's condition weakened.In tsipramil and unique side effects may manifest as: dry mouth, drowsiness, nausea, weakness, diarrhea, sweating, tremor, insomnia, sexual dysfunction.

By receiving feedback Cipramil therapy may cause a slight reduction in heart rate.In patients with a low heart rate can cause reception tsipramil bradycardia.

extremely rare when using large doses may cause seizures.

obtained overdose Tsipramilom reviews show the probability of the following symptoms:

  • drowsiness;
  • violation of articulation;
  • coma;
  • increased sweating;
  • sinus tachycardia;
  • nausea and vomiting;
  • hyperventilation;
  • cyanosis.

specific antidote does not exist, it is recommended symptomatic lechenie.Posle oral gastric lavage formulation is recommended to do as quickly as possible.

Cipramil Interaction with other drugs

About chemical incompatibility tsipramil comments have been received.Tsipramil combination with monoamine oxidase inhibitors can cause hypertensive crisis.

not identified tsipramil interaction with alcohol, but alcohol is not recommended during treatment.In clinical trials there was no evidence of pharmacodynamic interaction with drugs kardiotropnyh.


Patients receiving antidepressant therapy, require careful medical supervision, especially at the beginning of the course, due to the likely clinical worsening symptoms and suicidal tendencies.

use of selective serotonin reuptake inhibitors in the third trimester of pregnancy may have a negative impact on the psychological and physical development of the child.In children whose mothers took during pregnancy Cipramil, registered the following disorders: tremor, irritability, hypertension, tearfulness, increased muscle tone, poor sleep.These disorders can occur as a result of the withdrawal syndrome.When using analog tsipramil pregnant should not be abrupt withdrawal.

Persons carrying out potentially dangerous work, care must be taken during the period of drug treatment.

Storage drug Cipramil

Store at temperatures up to + 30 ° C, out of reach of children.

Shelf life tsipramil

5 years.

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