12 August

GA- 40 - instructions for use , characteristics , indications

immunotherapeutic therapeutic drugs with anticarcinogenic.

preparation GA-40 is a complex of polypeptides isolated from ecologically clean plant material.GA-40 comprises a combination of a standardized chromatographically purified polypeptides.In medical practice, GA-40 is used as a clear, colorless solution.

General characteristics

main physical and chemical properties: dried white powder with a specific smell;

Composition: 1 vial contains 1 mg (1000 mcg) complex polypeptides HA-40, isolated from the extract (1:40) Solomon's seal ring (Polgonatum varticillatum);Excipients: sodium chloride, potassium dihydrogen phosphate.

Product form.Lyophilized powder for solution for injection.

Pharmacotherapeutic group.Antineoplastic drug.Code AST L01S.

Pharmacological properties

Preclinical and clinical trials suggest that therapeutic drug GA-40 in relation to the tumor cells characterized by cytostatic activity, and an immunomodulator refers to drugs or immunocorrectors immunoreabilitatsionnyh ty

pe.

GA-40 restores the performance of T and B cell immune systems.In particular, in the blood normalized quantitative indicators of T-common, T-active T-helper, T-cytotoxic, T-suppressor cells, normal killer cells (NK-cells), leukocytes, macrophages, platelets, eosinophils, basophils, stab segmented, monocytes;GA-40 restores the content of immunoglobulins in the blood erythrocyte sedimentation rate decreases, stimulates the production of cytokines, including c-interferons and tumor necrosis factor (TNF-a).

Unlike chemo antineoplastic drugs GA-40 does not damage the normal cells of the body that determines its virtually harmless effect on any organs and tissues.

GA-40privodit the norm violated various negative factors, many biochemical blood parameters: total protein, albumin, globulin, urea, creatinine, total bilirubin, free and conjugated bilirubin, glucose, and the following marker enzymes - alanine aminotransferase (ALT), aspartate aminotransferase (AST), g-glyutamintranspeptidazy (g-GP), alkaline phosphatase.

the treatment preparatomGA-40 is observed positive dynamics of carcinoembryonic antigen (CEA), a-fetoprotein (AFP), prostate-specific antigen (PSA), and other specific tumor markers.GA-40 is also a positive effect on the blood content of sodium, calcium, potassium, and other minerals.

Indications

GA-40 is used:

In the treatment of malignant tumors.

GA-40 gives you a chance to improve the condition of patients, even in the advanced neoplastic processes, the treatment of which exhausted the possibility of major conventional methods.GA-40 is characterized by a dual effect on tumor formation: a direct effect on tumor necrotic epithelial tissue of all organs (ie carcinomas, but sarcomas - a tumor of the connective tissue - GA-40 does not have a direct effect), and indirectly, through the activation of antitumorimmunity to all organs and tumor types, except for some types of leukemia.GA-40 inhibited the growth of malignant cells, promotes regression of tumors and metastasis resorption, reduces pain, improves the quality and increases the life expectancy of patients.

Application of GA-40 is recommended prior to surgery as a form of primary malignant tumors hidden metastases in the body have already been distributed (70%), although their progressive development of the primary tumor is suppressed.Moreover, the primary tumor is reduced or even disables the anti-tumor immune mechanisms.GA-40 normalizes the immune system and promotes the resorption of hidden metastases, thus the primary tumor is localized.Application

GA-40 is recommended as after surgery as postoperative stress, particularly in the first week, usually causes a significant decrease in immunity, which increases the risk of infections and of new metastases.Postoperative use of GA-40 prevents the spread of metastasis and accelerates postoperative recovery processes.

Application of GA-40 is recommended both before radiotherapy and chemotherapy during their implementation and after their completion.

toxic effects on the body with cancer chemotherapy and radiotherapy often cause severe complications and is therefore forced to delay or even stop the treatment.Another problem - the initial resistance of certain tumor cells used for therapeutic drugs, as well as the resistance acquired during treatment.Radiotherapy and chemotherapy also cause genetic mutations in normal cells and, as a consequence, increases the probability of a qualitatively new types of tumors.Application

GA-40 in combination with radiotherapy and chemotherapy significantly reduces the toxic effects of these therapies, the possibility of their use and efficiency are increased;organism is largely protected from the occurrence of new tumors.

the treatment of certain types of leukemia.

GA-40 as a monotherapy or in combination (in conjunction) with other types of therapies used in the treatment of acute myeloid leukemia and megacaryoblastic.When using the drug GA-40 stimulation gemapoeza noted processes, as well as in malignant cell transformation of normal body cells.

the treatment of non-malignant and other neoplasms - mastitis, fibroma, myoma, adenoma, tsistozy etc.

the treatment of allergic diseases -.. Bronchial asthma, etc.

the treatment of infectious and inflammatory diseases of acute and chronic viral hepatitis (Hepatitis A, B, C) tsiroz different origin, pneumonia, bronchitis, tuberculosis, stomach ulcers and dvenadtsitiperstnoy ulcer, cholecystitis, prostatitis, trihomonioz, chlamydiosis, toxoplasmosis, cystitis, and others.)

GA-40 is used for preventive safe treatment for a genetic propensity toneoplastic disease, is closely linked to environmental factors.At any age in humans and reborn hundreds of cancer cells are formed every day, that in people with a normal immune system immediately detected and destroyed.The probability of occurrence of tumors in humans with weakened and the more defective immunity is quite large.To reduce the risk of cancer and non-specific disease, as well as to increase resistance to viral and other infectious diseases is recommended twice per year a course of treatment with GA-40, especially in persons over the age of 40-50 years.

rank therapeutic monoeffekta GA-40 cancer patients at stages 3-4.

  • best effect (significant improvement) -12%
  • good effect (improvement) - 33%
  • Satisfactory effect (stabilization process) -46%
  • Lack of effect - 9%
  • negative effect (deterioration) - 0%

Dosing

GA-40 is used in the form of subcutaneous or intramuscular injection.Each vial containing the lyophilized powder is added 5 ml of water for injection, gently shaken until fully dissolved powder.The dose of a single injection of 2 mg / kg body weight (0.01 ml / kg body weight).A treatment course of 21 injections, which are held by the scheme prescribed by the physician.Treatment continues until the complete remission of tumors and other diseases.Typically, the treatment involves at least 7 courses, with pauses between 10-14 days after which in order to prevent repeated courses are recommended one-time intervals of 2-4 months.

Contraindications

Application of GA-40 is contraindicated during pregnancy.

Side effects

the treatment preparatomGA-40 side effects were observed.GA-40 improves the structural and functional parameters of all the vital organs.This ensures the effectiveness and safety of treatment is not only a primary disease but also eliminates the side effects in the case of GA-40 alone and in kombinatsiiGA-40 with other drugs and the traditional methods.

Product form

GA-40 is produced in the form of a lyophilized powder, or 0.02% of the finished solution for injection in vials.

Terms and Conditions of storage

drug should be stored in a dark place at a temperature between 4o to + 10oC.

Shelf life: powder 12 months, in the form of an injection of 2 months.

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