14 October

L-lysine aescinat - instructions for use , indications, dosage

L-lysine aescinat - angioprotective drug with venous and moderate hypoglycemic action.

release form and composition

Formulation - concentrate for solution for intravenous (i / v) administration (5 ml ampoules in blisters 5 pieces, in a cardboard bundle two packaging.).Active substance

- L-lysine aescinat in 1 ml of concentrate - 1 mg.

Indications

  • traumatic or post-operative swelling of the brain or spinal cord;
  • soft tissue swelling of various localization of post-operative and post-traumatic origin;
  • Swelling on the background of the disorder of the peripheral venous circulation.

Contraindications

  • severe impaired renal function and / or liver disease;
  • Bleeding;
  • Pregnancy and breast-feeding;
  • the age of 18;
  • intolerance of components.

Dosage and Administration

L-lysine aescinat intended only for the on / in the slow drip or bolus.It is strictly forbidden intraarterial!

recommended daily dose - 5.10 ml.

Do not use the drug without prior dilution.

solution for the on / in

the concentrate is prepared by dissolving in 0.9% sodium chloride solution:

  • solution for infusion: 50-100 ml;
  • solution for bolus: 10-15 ml.

should be increased to 20 ml in traumatic brain injury, post-operative swelling of the spinal cord and brain with symptoms of edema, swelling, extensive soft tissue swelling due to injury and other life-threatening conditions of the patient and the daily dose is administered in equally in 2 divided doses.The course of the drug depends on clinical indications and effectiveness of treatment and may last from 2 to 8 days.

Side effects

Against the background of individual intolerance of L-lysine aescinat may develop undesirable effects:

  • Nervous System: tremor, dizziness, headache;in rare cases - a short-term loss of consciousness, ataxia;
  • Digestive system: nausea;in rare cases - diarrhea, vomiting;
  • Respiratory System: isolated cases - shortness of breath, dry cough, feeling short of breath, bronchial obstruction;
  • Hepatobiliary system: increased activity of transaminases and bilirubin;
  • Cardiovascular system: decrease in blood pressure (BP), tachycardia, increased blood pressure, chest pain;
  • Allergic reactions: itching, petechial, or papular erythematous skin rash, hives, fever, flushing of the face and lips;in rare cases - anaphylactic shock, angioedema;
  • Local reactions: burning sensation along the vein (for administration), pain in the arm, phlebitis;
  • Other: fever, general weakness, chills.

Cautions

Appointment drug to patients with hepatocholecystitis in some cases may cause a transient increase in bilirubin and transaminases, which is not a threat and does not require discontinuation of therapy.

The composition concentrate includes ethanol in the amount of 23.8% or up to 2.4 ml in single and up to a daily dose of 6.1 ml.

Precautions should be prescribed the drug for epilepsy, alcoholism, liver disease.

The use of L-lysine aescinat may affect the patient's ability to drive vehicles and mechanisms.

Drug Interactions Aminoglycosides

while the use of L-lysine aescinat can improve their nephrotoxicity.

At long previous treatment with anticoagulants or necessity of their combination with the drug dose should be adjusted under control of anticoagulants prothrombin index.

Concomitant antibiotic cephalosporin therapy hinders the binding of L-lysine aescinat to plasma proteins and increases the risk of its side effects, with increased concentration of free escin in the blood.

should take into account the presence of 96% ethanol in the composition of the drug, while the appointment of other drugs.

Terms and conditions of storage

Store in a dark place at a temperature of 15-25 ° C.Keep away from children.

Shelf life - 2 years.

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